Abstract
<jats:p>Abstract. The kidneys play a vital role in the body's functioning. They are involved in maintaining homeostasis. Renal failure leads to impairment of multiple renal functions, which impacts the entire body. This is a particularly serious problem in pediatric nephrology. More than 13% of the world's population suffers from renal failure, including children. The aim of Monitoring renal impairment in children is a very important topic. Since the literature largely focuses on signs and symptoms, diagnosis, treatment, and preventive examinations, it is important to focus on the most common renal impairments and the underlying causes of their development. To identify renal impairment in children, biochemical analysis of certain blood parameters was performed. Materials and Methods. The studies were conducted in the clinical biochemistry laboratory and nephrology department of the National Center for Maternal and Child Health from 2022 to 2024. Eighty children aged 2 to 16 years served as subjects. Total protein, urea, and creatinine levels were analyzed using the Jaffe method on Mindray BS-430 and BS-240 devices. Results. Comparative analysis of the parameters of children with renal impairment and healthy patients is a multifaceted research approach based on the comparison of various biochemical, clinical, and instrumental data. This helps identify key differences in children's health and kidney disease, as well as identify the characteristic features and development of pathologies.</jats:p>