2,5-DIMERKAPTO-1,3,4-TIADIAZOLNI GIDRAZINLI KOMPLEKSINI BIOLOGIK FAOLLIGINI IN SILICO USULLAR YORDAMIDA BAHOLASH

Authors: Raxmatullayeva O.U, Jaloliddinov F.Y, Babayev B.N et al.

Publication: INTERNATIONAL JOURNAL OF SCIENCE AND TECHNOLOGY

Published: May 4, 2026

Source: Crossref

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Abstract

<jats:p>Ushbu ishda 2,2’-((1,3,4-tiadiazol-2,5- diyil)bis(sulfandiyil)) di(atsetogidrazid) birikmasining biologik faolligi kompyuter modellashtirish usullari yordamida o‘rganildi. PASS Online natijalari moddaning serebral antiishemik va sitoprotektor xususiyatlarini ko‘rsatdi. Molekulyar dokking tahlillari PTP1B oqsili bilan yuqori bog‘lanish energiyasini (-7.7 kkal/mol) aniqladi, bu esa birikmaning diabetga qarshi potentsialini tasdiqlaydi.</jats:p>

Keywords

ushbu ishda 22134tiadiazol25 diyilbissulfandiyil diatsetogidrazid

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2,5-DIMERKAPTO-1,3,4-TIADIAZOLNI GIDRAZINLI KOMPLEKSINI BIOLOGIK FAOLLIGINI IN SILICO USULLAR YORDAMIDA BAHOLASH

Abstract

Keywords

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