Abstract
<jats:p>This article discusses the applications of pyridine derivatives in agriculture, medicine, and industry, as well as modern syntheticmethods for their preparation. The low reactivity of pyridine as a π-electron-deficient heterocyclic compound toward electrophilicreactions and the dependence of its oxidation processes on reaction conditions were analyzed. The study investigates the oxidationof pyridine in the presence of hydrogen peroxide and formic acid, and the step-by-step mechanism of pyridine N-oxide formationis described. The influence of reaction conditions (temperature, time, and reagent ratio) on product yield was determined, withoptimal conditions identified as 80°C and 12 hours, achieving a yield of 84–86%. The structure of the obtained product wasconfirmed by IR spectroscopic analysis. The results demonstrate an efficient and optimized method for the synthesis of pyridineN-oxides.</jats:p>