AGE-RELATED MORPHOLOGICAL REMODELING OF RENAL TISSUE DURING CHRONIC CARBON MONOXIDE EXPOSURE

<jats:p>&lt;p&gt;Chronic carbon monoxide exposure induces persistent tissue hypoxia, resulting in structural remodeling of the kidney. The severity of renal injury largely depends on age-related adaptive capacity of the nephron. The present study aimed to evaluate age-related morphological alterations of renal tissue following chronic carbon monoxide exposure.&lt;/p&gt;&lt;p style="text-align: justify;"&gt;The study was carried out on 3- and 9-month-old male albino rats. Histological and morphometric analyses were performed to assess glomerular architecture, Bowman's capsule space, tubular morphology, and interstitial tissue.&lt;/p&gt;&lt;p style="text-align: justify;"&gt;The results demonstrated that renal alterations in 3-month-old animals were predominantly adaptive, whereas 9-month-old rats exhibited more pronounced glomerular remodeling, widening of Bowman's capsule space, tubular epithelial degeneration, and interstitial expansion. Morphometric analysis confirmed that the severity of hy­poxia-induced structural remodeling increased with age.&lt;/p&gt;</jats:p>