Abstract
<jats:title>Abstract</jats:title> <jats:p>Social media has an estimated global user base of 3.5 billion. Adolescents, constituting over 90% of this group, and thereby university students. are extensively involved in social media use, emphasizing its significance in their daily lives. Excessive use of social media poses risks such as depression, affecting academic performance.</jats:p> <jats:p>The objective of this study was to determine the association between social media use and depression among university students in Urban Northern Tanzania.</jats:p> <jats:p>This was a cross-sectional study that involved university students from three universities. Data was collected through an online close-ended questionnaire. Statistical analysis included the use of frequencies, percentages, chi-square and bivariate logistic regression at 95% confidence intervals (CIs) and significance at p-value <0.05.</jats:p> <jats:p>A total of 384 participants were enrolled in the study. 36.7% reported that they used social media for 1 to 3 hours daily. 58.1% of all participants reported high frequency of social media use for social purposes. 29.2% of university students who participated in the study were screened to have depression. The prevalence of depression increased with longer daily duration of social media use. Those using social media for more than 5 hours daily, had 3.049 times higher odds of being depressed. Moderate frequency of social media use for social purposes was linked to reduced depression.</jats:p> <jats:p>Daily duration of social media was significantly associated with depression levels among university students. Significant associations were also found between moderate use of social media for socializing, with lower risk of depression. We recommend that universities develop targeted mental health interventions and promote balanced, purposeful social media use among students.</jats:p>