Abstract
<jats:p>Background: Randomized controlled trials (RCTs) that rely on fabricated or fictitious data, commonly known as zombie trials, threaten evidence-based medicine by contaminating systematic reviews and clinical guidelines. We describe a cohort of zombie trials with confirmed data fabrication. Methods: The cohort was derived from the Retraction Watch database by updating and extending the dataset used in the VITALITY study to include all retracted zombie trials identified from database inception through December 11, 2025. To ensure that included RCTs were identified as zombie trials rather than retracted for other reasons, retraction notices were text-mined for terms indicative of data fabrication. Trial- and author-level characteristics were extracted using a combination of automated and manual methods by one reviewer. We applied descriptive statistics, coauthorship network analysis, and cascade effect mapping. Results: Among 236 retracted RCTs published between 1983 and 2024 and identified as zombie trials with confirmed data fabrication, 197 (83.5%) were associated with authors who had a history of repeated misconduct. These trials involved 450 authors overall, including only 66 unique first authors, with one author alone accounting for 104 trials (43.8% of the cohort). Authors associated with multiple zombie trials experienced substantially longer delays to retraction, with a median of 13.6 years (IQR 8.0-15.3), compared with 2.75 years for authors linked to a single zombie trial. Most retracted zombie RCTs were monocentric (91.9%), involved a median of 3.5 authors per trial, and predominantly evaluated pharmacological interventions. They were largely concentrated in anesthesiology (58.1%) and in Japan (56.4%). Adjusted for the volume of trials produced by country, Japan, Tunisia, and Egypt had the highest rates. Coauthorship networks formed fragmented, largely disconnected clusters, suggesting localized factories of fabricated evidence. Retraction cascades were common, with the identification of a single fraudulent trial often leading to chains of retractions that exposed misconduct spanning decades. Conclusion: Confirmed zombie trials were usually generated from single centers that published many such trials.</jats:p>