Abstract
<jats:p>Traumatic brain injury (TBI) is a leading cause of death and long-term disability in children, with many experiencing persistent symptoms even after mild TBIs. Exposure to adverse childhood experiences (ACEs) can have physiological effects that may alter how the brain responds to injury, yet the effects of ACEs on white matter injury and recovery processes remain unclear. This study examined whether a history of ACEs is associated with patterns of longitudinal change in white matter microstructure in children with mTBI. Ninety-six concussed adolescents (mean age=14.9 years, range =11.4-17.9, 51% female) from the CARE4Kids consortium completed the Pediatric ACEs and Related Life-Events Screener and underwent diffusion-weighted MRI at baseline (7-35 days after injury) and follow-up (2 months later). Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), radial diffusivity (RD), orientation dispersion index (ODI), and intracellular volume fraction (ICVF) were estimated using tract-based spatial statistics and harmonized across sites. Differences in the magnitude and direction of change in diffusion metrics over time were examined in 15 tracts of interest. Higher ACE exposure was associated with smaller absolute change in AD, MD, ODI, and ICVF across several white matter tracts, including the corpus callosum, internal and external capsules, corona radiata, and posterior thalamic radiation. Groups did not differ in the direction of white matter change for any tract-metric combination. These findings suggest that ACE exposure may blunt white matter reactivity to injury and/or reorganization during recovery processes.</jats:p>