Beyond reductions in depressive symptoms: Functional, social, and household outcomes in a pilot cluster-randomized controlled trial of group interpersonal psychotherapy in rural Uganda

<jats:p>Introduction: Group interpersonal psychotherapy may improve outcomes beyond depressive symptoms, but evidence on functioning, social support, and household welfare remains limited. We examined these outcomes using mixed methods in a pilot cluster-randomized controlled trial of a six-week intervention in rural Uganda. Methods: Twenty-four villages were randomized to group interpersonal psychotherapy or enhanced care as usual. Eligible participants were female, aged at least 13 years, with Patient Health Questionnaire-9 scores of 10 or more. Outcomes were assessed at baseline, two weeks, and three months after treatment. Regression models used village-clustered standard errors. Exploratory sensitivity analyses compared controls with 33 intervention participants assessed independently of facilitators and after an honesty and confidentiality prompt. Fourteen interviews and three focus group discussions with 30 intervention participants were analysed thematically and integrated by outcome domain. Results: Of 292 randomized participants, 263 completed the three-month assessment. Intervention participants had lower anxiety scores than controls at three months (mean difference -7.18; p&lt;0.001), higher subjective wellbeing (mean difference 3.70; p&lt;0.001), lower disability scores (mean difference -1.01; p&lt;0.001), greater perceived social support (difference 23.4 percentage points; p&lt;0.001), and more meals reported for children in the previous 24 hours (mean difference 0.62; p&lt;0.001). Household food insecurity was lower in the full-sample analysis (difference -23.3 percentage points; p=0.008), but not in the exploratory sensitivity analysis (difference 1.5 percentage points; p=0.883). Qualitative accounts described recovery as restored capacity to work, manage relationships, care for children, and respond to hardship despite material constraints. Conclusions: These preliminary findings suggest that group interpersonal psychotherapy may improve outcomes beyond depressive symptoms, although household welfare findings were less consistent. Larger trials with independent outcome assessment and longer follow-up are needed. Trial registration: The trial was retrospectively registered with the Pan African Clinical Trials Registry (PACTR202606549854263) on 29 June 2026.</jats:p>