Abstract
<jats:p>Infantile seizures have diverse etiologies, but when structural, metabolic, and infectious origins are excluded upon initial evaluation, genetic testing through rapid genome sequencing or comprehensive epilepsy panel has become increasingly recommended. Advances in genomic medicine have led to the identification of numerous candidate genes associated with epilepsy, although interpretation of variants—particularly those of uncertain significance—remains challenging. We present the case of a previously healthy 4-month-old female with recurrent seizures whose epilepsy panel revealed rare heterozygous variants in MAGEL2, ADGRV1, and a novel PRICKLE2 (p.Gly152Ser) variant. This report highlights the complexity of variant interpretation and the potential role of emerging epilepsy-associated genes.</jats:p>