Managing SRI-Induced Sexual Dysfunction: Substitution, Antidotes, and Modifiable Factors

<jats:p>One in five patients stops their antidepressant due to orgasm difficulty or loss of libido, so screen for these at every visit. Avoid dose reduction and drug holidays as strategies for managing medication-induced sexual dysfunction. These approaches often lead to relapse or medication discontinuation. Reserve off-label antidotes such as buspirone, testosterone, sildenafil, or DHEA for patients responding well to their current SRI who have failed prior antidepressant trials.</jats:p>