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Abstract
<jats:p>After completing this activity, participants should be able to: Apply a TSH-first testing protocol in patients with mood, anxiety, and psychotic disorders, and interpret free T4 and anti-thyroid antibody results to identify clinical and subclinical thyroid dysfunction. Assess whether a thyroid abnormality is contributory or comorbid, distinguishing euthyroid sick syndrome from true hypothyroidism and recognizing hyperthyroid presentations that may be mistaken for anxiety or mania. Integrate T3 and T4 augmentation into the care of treatment-resistant depression and rapid cycling bipolar disorder, applying dosing, titration, and monitoring parameters, including thyroid replacement in lithium-induced hypothyroidism.</jats:p>