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Abstract
<jats:p>Relevance. It is widely recognized that intraocular hemorrhages of various localization play a significant role in the pathogenesis of complications in diabetic retinopathy (DR). Many authors associate the frequency of complications with the development of neovascularization in the preproliferative and proliferative stages of diabetic retinopathy. Purpose of the study. TTo study some aspects of the pathogenesis of diabetic retinopathy (DR), namely the vascular-platelet link of the hemostasis system and to develop a method for the prevention and treatment of hemorrhagic complications. Materials and methods. TThe study included 122 eyes (61 patients) with type 2 insulin-dependent diabetes mellitus (DM), including 11 patients (22 eyes) with intact fundi (control). Evaluative tests of the hemostasis system were used to assess its condition. Results. The inclusion of antiplatelet agents (APAs) in the therapy arsenal led to a significant restoration and stabilization of hemostasis system indicators. Conclusion. Platelet activation through the "in vitro" administration of a 1% ATP solution contributes to increased platelet functional activity, suppression of angiogenesis and hemorrhage. It also activates fibrinolysis and disrupts microthrombi.</jats:p>