Մուկոզ մեմբրանոզ պեմֆիգոիդի կլինիկական դրսեվորումը եվ բուժման արդյունքները

<jats:p>Mucous membrane pemphigoid is a chronic, autoimmune, cicatricial conjunctivitis. It is usually bilateral and may be asymmetrical. Mucous membrane of other organ systems (oral cavity, pharynx, genitalia, anus) are also commonly affected. In about 15% of cases, the skin may also be involved. It mainly manifests itself in people aged 60-80 years, but is rarely found in individuals under 30. There is no racial predisposition. There are 2 clinical scoring systems for mucous membrane pemphigoid (schema from Foster and Mondino). The diagnosis of the disease made based on clinical signs, positive, direct immunofluorescence test of the conjunctiva and biopsy of the involved tissues (lower eyelid, oral mucosa). Treatment of mucous membrane pemphigoid is carried out with local (artificial tears, steroid and cyclosporine drops) and systemic (corticosteroids, immunosuppressants, cytostatics and biological drugs) medications. During 2002-2025, 9 patients (8 women and 1 man) with mucous membrane pemphigoid were examined and treated in the Department of Inflammatory Disease of the Ophthalmological Center after S.V. Malayan. The patients were at different stages of disease development. The first stage of development is characterized by a mild, nonspecific, conjunctivitis-like picture, which can lead to an incorrect diagnosis. Therefore, a thorough anamnesis, early and correct local and systemic treatment of the disease is very important and can prevent the development of symblepharon, ankyloblepharon and subsequent complications.</jats:p>