Genetic Predisposition to the Development of Idiopathic Osteoarthritis of the Knee and Hip: a Review

<jats:p>Osteoarthritis is a degenerative joint disease that leads to damage to cartilage tissue and changes in the structure of bones, ligaments and muscles that surround joints. Despite numerous studies of osteoarthritis in our country and abroad, the wide variability in the development of the disease does not give a clear picture of the true cause of osteoarthritis formation. In the available domestic literature, there is still almost no information about genetic factors in the development of osteoarthritis. In this literature review, we discuss some evidence suggesting a genetic association with the risk of knee and hip osteoarthritis and summarize recent advances in this field, with special emphasis on genetically associated studies.</jats:p>