Clinical and oncological outcomes in colon cancer: Impact of tumor location and family history in a retrospective cohort

<jats:p>Introduction In colorectal cancer, right-sided primary tumor location is associated with a worse prognosis compared to left-sided colon cancer. Objective: In this study, we compared clinical, pathological, oncological characteristics, and survival between cancers of the left and right colon. Methods: Patients who underwent curative resection for colon cancer were identified and retrospectively analyzed. Clinicopathological characteristics, overall survival, postoperative complications, and postoperative liver metastasis were compared between left- and right-sided tumors using the log-rank test and multivariable Cox proportional hazards regression. Results: A total of 108 patients with colon adenocarcinoma were included. There was no difference in overall survival (hazard ratio [HR] = 1.08, 95% confidence interval [CI]: 0.68&amp;ndash;1.73, p = 0.72) between right- and left-sided primary tumors. Postoperative liver recurrence was noted in 24.1% of cases, and postoperative complications occurred in 6.5% of patients, without significant differences between groups. Higher body mass index (odds ratio [OR] = 2.31, 95% CI: 1.05&amp;ndash;15.32, p = 0.031) and larger tumor size (OR = 5.32, 95% CI: 2.82&amp;ndash;11.14, p = 0.001) were significantly associated with colon cancer risk. Additionally, a positive family history of cancer was significantly associated with decreased overall survival (HR = 2.44, 95% CI: 1.16&amp;ndash;5.12, p = 0.018). Conclusion: Tumor localization was not associated with overall survival among colon cancer patients who underwent curative resection. However, a positive family history of cancer was associated with overall survival.</jats:p>