Abstract
<jats:p>This pragmatic randomized trial compared a culturally adapted Mindfulness-Based Health Promotion (MBHP) program to an active psychoeducational control. In intention-to-treat analyses, both groups showed improvements in quality of life from baseline; however, between-group differences in WHOQOL-BREF domains were not statistically significant after adjusting for baseline. Exploratory secondary analyses, corrected for multiplicity via false-discovery-rate control, showed that MBHP conferred significantly greater improvement than the active control on three of seven QASCI caregiver-burden subdomains (Emotional Overload, Personal Life Impact, and Family Support), while the QASCI total score and remaining subdomains did not differ significantly between groups. The intervention was feasible and acceptable, with no adverse events reported. Findings support the pragmatic delivery of MBHP within rehabilitation services while highlighting the need for longer follow-up and replication with enhanced allocation concealment.</jats:p>