Non-melanoma Skin Cancer of the Face: Clinical and Organizational Aspects

<jats:p>Non-melanoma skin cancer (NMSC) of the face represents a significant medical and social challenge due to its high prevalence, local aggressiveness, and considerable impact on patients’ quality of life. A major difficulty lies in accurately defining tumor margins, which directly affects the radicality of surgical intervention and the aesthetic outcome. In this context, the use of the photosensitizer Chlorin E6 appears promising, as it combines the properties of fluorescent navigation and photodynamic action. The objective: to evaluate the effectiveness of a combined approach to surgical treatment of facial NMSC using the photosensitizer Chlorin E6, which integrates fluorescent navigation and photodynamic action. An additional objective was to assess the role of primary care in early detection and patient referral. Materials and methods. A prospective, stratified, non-randomized study was conducted with long-term follow-up (2018–2025). The main group (n = 40) received intravenous Chlorin E6 (1 mg/kg), followed by fluorescent visualization of tumor margins and implementation of photodynamic effect. The control group (n = 27) underwent standard surgical treatment. The diagnostic protocol included clinical examination, morphological verification, and ultrasound examination of regional lymph nodes. Primary care physicians performed initial screening and patient referral. Results. In the main group, improved precision in delineating tumor margins, reduced recurrence rates, and improvement in aesthetic outcomes were achieved. Most lesions were located on the nose and auricle, with early-stage tumors (T1, T2) predominating. The involvement of family physicians contributed to timely identification of suspicious lesions and effective patient routing to specialized care. Conclusions. The combined surgical strategy using Chlorin E6 shows promise for treating facial NMSC, offering high oncological efficacy, reduced recurrence risk, and preservation of functional and aesthetic facial parameters. Integration of primary care into oncological pathways enhances the quality of patient referral and preventive measures.</jats:p>