Iridium and Ruthenium Complexes bearing triazoles based on AZT and 5-fluorouracil

<jats:p>AZT- and 5-fluorouracil-derived pyridyl-triazole ligands were synthesized by copper-catalyzed azide–alkyne cycloaddition and coordinated to ruthenium(II) and iridium(III). The resulting complexes were obtained in moderate to excellent yields and characterized by NMR spectroscopy. Their antifungal activity was evaluated against Candida albicans and Candida glabrata and no significant activity was detected after 48 h. These results provide synthetic routes to new nucleoside-derived organometallic complexes but indicate that further optimization is needed to improve their antifungal activity.</jats:p>