Abstract
<jats:p>Vinyl chlorides and chloroalkynes serve as valuable synthetic intermediates across a broad range of chemical industries. Despite their importance, current methods for their preparation rely on the stoichiometric use of harsh chemical reagents, making the development of a catalytic method that operates under mild conditions highly desirable. In this work, we demonstrate that the vanadium-dependent chloroperoxidase from Curvularia inaequalis (CiVCPO) is an effective catalyst for the decarboxylative chlorination of cinnamic acids and acetylenic acids. This biocatalytic protocol proceeds in moderate to excellent yield and with excellent chemoselectivity. Furthermore, we show that this enzymatic platform can be seamlessly extended to decarboxylative bromination reactions.</jats:p>