Abstract
<jats:p>The manipulation of liquid–liquid interfaces through supramolecular approaches offers new avenues for enhancing emulsion properties that surpass those achieved with traditional surfactants. Here, we present the formation of a nano-ion composed of cyclohexanohemicucurbituril and PF6-, which significantly reorganizes the sodium taurodeoxycholate (NaTDC)-stabilized oil–water interface. This reorganization facilitates the rapid generation of monodisperse tributyrin (TB) nanoemulsions with an average droplet size of ~150 nm. In contrast, without the nano-ion, NaTDC leads to the formation of micron-scale droplets that coalesce within one day, while nano-ion–stabilized emulsions maintain stability for several months. This enhancement in kinetic stability indicates the creation of a reinforced interfacial layer, where the supramolecular assembly effectively anchors and restructures the bile-salt film. Furthermore, the nano-ion confers biological functionality to the droplets, allowing for the inhibition of human pancreatic enzymes, a crucial factor in reducing body weight and postprandial hypertriglyceridemia. Our findings demonstrate the potential of interfacial supramolecular chemistry in developing dual-function emulsifiers that combine robust colloidal stability with significant biological activity. This study lays the groundwork for potential applications of triglyceride-based nanoemulsions in pharmaceutical</jats:p>