Abstract
<jats:p>In this study, three novel chelators (Me2paTACN, H2pypTACN, and Me2pypTACN) based on the 1,4,7-triazacyclononane (TACN) ligand platform have been introduced. The ligands contain picolinate and phosphonated pyridine chelating arms, to provide an optimal five-coordinate geometry for Cu(II). The solution chemistry of these complexes was systematically investigated using spectrophotometric titrations, UV-vis spectroscopy, electron paramagnetic resonance (EPR), and cyclic voltammetry (CV). Then, these ligands were employed in 64Cu radiolabeling studies and subsequent in vivo positron emission tomography (PET) imaging studies, to reveal that the</jats:p>
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Keywords
ligands
studies
study
three
novel