Abstract
<jats:p>Cyclic-minipeptide-conformer candidates targeted ebola virus (EBOV) GP2 prefusion homotrimer-interfaces implicated in viral fusion to host membranes. GP2 homotrimer, homodimer and αhelix interfaces were targeted by BoltzGen co-generating candidates predicting < nanoMolar affinities. Additionally, cyclicminipeptides provide easy chemical synthesis and high environmental and endoprotease stability that may facilitate in vitro and in vivo assay validations. Therefore, cyclic-minipeptide candidates may be instrumental to computational-guide further developments toward EBOV-specific drugs. Because their many contacts to GP2 highly conserved amino acids, these may be also candidates to detect EBOV pan-variants and even avoid crossreactivities with pan-hemorragic fever viral diseases and highly abundant fluid proteins in humans.</jats:p>