ROLE OF OSTEOCLASTS IN THE PATHOGENESIS OF BONE DISORDERS IN GAUCHER DISEASE

<jats:p>Gaucher disease (GD) is a hereditary lysosomal disorder caused by glucocerebrosidase deficiency and accumulation of glucosylceramide in macrophages. One of the most common and clinically significant manifestations of the disease are skeletal lesions, including osteopenia, bone pain, fractures, osteonecrosis, and bone deformities. Despite the use of pathogenetic therapy, bone complications may persist in the majority of patients. An important role in their development is played by disturbances in bone remodeling associated with increased osteoclastogenesis and chronic immune system activation. This review discusses current concepts of osteoclasts and the immune system in GD, as well as their significance for the development of new therapeutic approaches.</jats:p>