Relationship between vitamin D levels and fractalkine in patients with primary hypothyroidism, Взаємозв’язок між забезпеченістю організму вітаміном D та концентрацією фракталкіну у хворих на первинний гіпотиреоз

<jats:p>Background. Primary hypothyroidism is one of the most common endocrine diseases and is accompanied by the development of numerous metabolic disorders. One of the promising biomarkers of vascular inflammation is fractalkine (CX3CL1). Its role in primary hypothyroidism has not been studied sufficiently, and data on relationship with thyroid status, vitamin D levels, and lipid metabolism indicators remain controversial. The purpose of the study was to assess the effect of vitamin D status on fractalkine concentration in patients with primary hypothyroidism. Materials and methods. One hundred and thirty patients with primary hypothyroidism aged 18 to 65 years were observed. All participants were tested for thyroid-stimulating hormone, free thyroxine, cholecalciferol, and CX3CL1. Statistical methods included the formation of an electronic database, checking the distribution of indicators for normality, and calculating average values and variability indicators. Results. The lowest CX3CL1 values were observed in patients with sufficient levels of 25(OH)D (≥ 30 ng/ml), while in those with insufficiency and especially vitamin D deficiency, a progressive increase in the concentration of the studied chemokine was noted. The maximum CX3CL1 values were recorded in patients with a 25(OH)D level of less than 20 ng/ml. An inverse correlation was found — with a decrease in vitamin D concentration, there was an increase in CX3CL1 levels. This confirms the possible involvement of vitamin D deficiency in the mechanisms of activation of systemic inflammation and the development of endothelial dysfunction in patients with primary hypothyroidism. Conclusions. Vitamin D insufficiency and deficiency are common among patients with primary hypothyroidism and are accompanied by increased levels of fractalkine. An inverse correlation was found between the concentration of 25(OH)D and fractalkine. The feasibility of a comprehensive assessment of thyroid status, vitamin D, and fractalkine levels is justified for personalizing approaches to the management of patients with primary hypothyroidism and timely identification of individuals at increased risk of cardiovascular complications.</jats:p>