Abstract
<jats:p>INTRODUCTION: Rebound pain developing after the resolution of regional blockade is an adverse effect that increases patients’ need for analgesics and reduces their satisfaction with postoperative pain management. First described in 2007, rebound pain remains a poorly studied phenomenon. OBJECTIVE: To summarize and analyze current literature on the incidence, mechanisms, risk factors, and preventive measures of rebound pain in patients undergoing surgery with regional anesthesia. MATERIALS AND METHODS: This review included publications indexed in PubMed, Google Scholar, and eLibrary (for Russian-language sources) that met the study objectives. RESULTS: The literature analysis revealed an average incidence of rebound pain of 40–50 %, identified risk factors such as young age, female sex, pre-existing pain, and certain types of surgical procedures, and determined the main strategies for its prevention. CONCLUSIONS: Rebound pain represents a significant clinical problem adversely affecting the early postoperative course. Prevention remains the cornerstone of management. The most promising approaches include the use of local anesthetic adjuvants, particularly dexamethasone, and systemic analgesics.</jats:p>