Abstract
<title>Abstract</title> <p>Oxidized regenerated cellulose (ORC) is a widely used absorbable hemostatic agent, but comparative data on its efficacy across different bleeding scenarios remain limited. This study compared the hemostatic efficacy, tissue compatibility, and safety of a domestically produced absorbable ORC (StypCel™) with an imported counterpart (Surgicel® Fibrillar™) in minipig models of liver, gastric wall, and mesenteric bleeding. Sixteen male Bama mini pigs were randomly assigned to StypCel™ or Surgicel® Fibrillar™ groups (n=8 each). Bleeding models were established for each organ, and outcomes including 10‑s blood loss, time to hemostasis, intraoperative blood loss, hematology, liver and kidney function, coagulation parameters, and histological changes were assessed. Both materials exhibited three‑dimensional porous network structures, with StypCel™ showing significantly finer fibers (9.82±0.93 μm vs. 20.59±1.88 μm, P<0.001). In liver, gastric wall, and mesenteric bleeding models, no significant differences were observed between groups in time to hemostasis (P=0.8759, P=0.1578, and P=0.9632, respectively), intraoperative blood loss (P=0.0805, P=0.7673, and P=0.4678, respectively), or any hematological, biochemical, or coagulation parameters at all time points (all P>0.05). Histological analysis revealed similar degradation and absorption profiles, with inflammation essentially resolved by week 4 in both groups. StypCel™ demonstrated equivalent hemostatic efficacy and comparable safety to Surgicel® Fibrillar™ across multiple bleeding models, supporting its use as an effective alternative.</p>