Abstract
<title>Abstract</title> <p>The use of three-dimensional (3D) printed biomaterial scaffolds to improve the effectiveness of drug delivery through their ability to release drugs over time and at specific locations has been gaining attraction. This study aims to develop a bioink based on gelatin–alginate for the medical applications of 3D printing drug-loaded scaffolds for localized breast cancer therapy. The formulated bioink also demonstrated good shear-thinning properties, printability, and structural stability, which allowed for the successful production of porous scaffolds with high shape fidelity. The printed scaffolds were analyzed by rheological analysis, Fourier transform infrared spectroscopy (FTIR), swelling, degradation, and drug release studies, and their results were characterized. The results showed effective incorporation of the drug, interconnected porous structure and sustained drug release, providing the scaffold with a potential for controlled local drug delivery. In summary, the developed gelatin–alginate bioink is an interesting platform for the 3D printing of therapeutic scaffolds for localized drug delivery.</p>