Closing the loop in wearable plasma therapy with a ZVS-Driven smart bandage for point of care burn management

<title>Abstract</title> <p> <bold>O</bold> ne of the major challenges in treating burns and bacterial infections is the need for innovative therapeutic solutions. While cold atmospheric plasma (CAP) technology has demonstrated promising effectiveness in sterilizing tissues and promoting their healing, its clinical adoption remains limited by the large size of conventional devices and the energy inefficiency required for portable applications. This paper presents the design and implementation of a wearable "Smart Bandage" system intended for burn treatment. The proposed system is based on a resonant "flyback" transformer operating with zero-voltage switching (ZVS) to minimize switching losses and maximize power density, driven by a low-voltage source (3.7 V). To ensure patient safety, an active closed-loop control strategy has been integrated that dynamically adjusts plasma properties based on vital signs (temperature, pH, and bandage integrity). Simulation results have demonstrated an energy conversion efficiency of 85%, enabling autonomous operation for up to 4 hours, in conjunction with a strict interrupt-based safety protocol with an error response time of less than 250 µs. This system maintains a safe therapeutic temperature (below 40°C) and provides a reliable engineering framework for wearable electronic medical devices. </p>