Abstract
<title>Abstract</title> <p> Seasonal Hyperacute Panuveitis (SHAPU) is a rapidly vision-threatening uveitis reported predominantly in Nepal, with uncertain aetiology and suspected association with white moths. We report a 36-year-old electrician who developed SHAPU following accidental exposure to white moths while repairing a tube light. He presented with severe vision loss, corneal haze, anterior chamber inflammation, and vitritis. Vitreous cultures were negative for bacterial and fungal pathogens, but PCR detected Human Herpesvirus 7, requiring valganciclovir. Although the patient initially showed signs of recovery, surgery was required to treat secondary angle-closure glaucoma. Progressive endothelial cell loss and cataract formation were successfully managed with phacoemulsification and intraocular lens implantation. Metagenomic sequencing of vitreous samples later identified <italic>Acinetobacter baumannii</italic> , although no additional treatment was required. After two years of follow-up, vision remained stable. This case report highlights significance of molecular diagnostics in detecting uncommon bacterial and viral infections in SHAPU and improving understanding of its complex aetiology. </p>