Abstract
<title>Abstract</title> <p> <bold>Background</bold> : Kaposi sarcoma (KS) is a vascular neoplasm associated with human herpesvirus-8 (HHV-8) and is most commonly encountered in patients with HIV infection or other forms of immunosuppression. Primary involvement of an intraparotid lymph node is exceptionally rare, particularly in HIV-negative individuals. We report an unusual case of isolated intraparotid nodal KS in a patient with chronic hepatitis B receiving antiviral therapy. <bold>Case Presentation:</bold> A 58-year-old HIV-negative man with chronic hepatitis B receiving antiviral therapy presented with a gradually enlarging left parotid mass of 3–4 months’ duration. Contrast-enhanced computed tomography demonstrated a well-defined enhancing lesion within the superficial lobe of the parotid gland. The patient underwent superficial parotidectomy with preservation of the facial nerve. Histopathological examination, supported by positive HHV-8 immunohistochemistry, confirmed Kaposi sarcoma arising in an intraparotid lymph node. Postoperative whole-body PET/CT, performed on two separate occasions, showed no evidence of residual tumor or systemic disease. <bold>Conclusion:</bold> This case highlights an exceptionally rare presentation of Kaposi sarcoma as an isolated intraparotid lymph node lesion in an HIV-negative patient with concomitant chronic hepatitis B receiving antiviral therapy. It expands the limited literature on this uncommon entity and emphasizes that Kaposi sarcoma should be considered in the differential diagnosis of atypical parotid masses, even in the absence of HIV infection or disseminated disease. </p>