Applicability of Mayo’s Autosomal Dominant Polycystic Kidney Disease (ADPKD) Prognostic Tool in the Southeast Asian ADPKD Population

<title>Abstract</title> <p>Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterised by progressive cyst growth leading to loss of kidney function. The Mayo Clinic ADPKD prognostic tool stratifies patients by risk of progression based on height-adjusted total kidney volume (HtTKV) and age. This study evaluated the tool's applicability in Southeast Asians using data from 50 Malaysian ADPKD patients. HtTKV was measured by MRI. Kidney function was estimated by CKD-EPI-based eGFR. The Mayo model eGFR strongly correlated with actual eGFR over 24 months (cc 0.748–0.815, p &lt; 0.001). Bland-Altman analysis showed high accuracy with P30 of Mayo eGFR values more than 90% of measured eGFR. Results indicate the Mayo prognostic tool provides accurate disease progression predictions in Southeast Asian ADPKD patients.</p>