Abstract
<title>Abstract</title> <p>Background Peripheral hemogram parameters have been widely investigated as prognostic biomarkers in glioblastoma (GBM). However, their association with tumor burden has not been fully characterized. This study evaluated the relationship between hematologic markers and tumor burden in patients with newly diagnosed IDH-wildtype GBM. Methods We retrospectively reviewed patients diagnosed with IDH-wildtype GBM. Preoperative magnetic resonance imaging (MRI) was used for volumetric assessment of contrast-enhancing (T1 C+) and T2-hyperintense lesions. Peripheral hemogram parameters, including white blood cell count (WBC), absolute neutrophil count (ANC), absolute lymphocyte count (ALC), absolute monocyte count (AMC), platelet count (PLT), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR), were analyzed. Age-adjusted partial Spearman’s rank correlation analyses were performed. Results A total of 297 patients were included. MLR demonstrated the strongest correlation with both T1 C+ volume (p = 0.001) and T2-hyperintense volume (p = 0.002). At 6-month follow-up, ANC exhibited the strongest correlation with both T1 C+ (p < 0.001) and T2-hyperintense volumes (p < 0.001). Conclusions MLR at diagnosis and ANC during follow-up, were significantly associated with GBM tumor volume. The findings support the potential utility of readily available hematologic biomarkers as adjunctive indicators of tumor burden and for disease surveillance in glioblastoma.</p>