Abstract
<title>Abstract</title> <p> Aggregation-caused quenching (ACQ) and poor aqueous solubility severely restrict electrochemiluminescence (ECL) applications of polycyclic aromatic hydrocarbons (PAHs). Herein, a water-induced supramolecular self-assembly strategy is proposed to address these drawbacks. Via a simple reprecipitation route, representative PAH meso-tetrakis(4-carboxyphenyl)porphyrin (TCPP) forms ordered supramolecular aggregates driven by noncovalent interactions, which suppress π–π stacking and ACQ and achieve a low triggering potential of − 1.0 V. Iron-based MOF supported molybdenum disulfide (MIL-101@MoS <sub>2</sub> ) is adopted as a multifunctional amplifier: reversible valence interconversion of Fe <sup>2+</sup> /Fe <sup>3+</sup> and Mo <sup>4+</sup> /Mo <sup>6+</sup> sustains continuous redox cycling to improve redox activity, while abundant oxygen vacancies accelerate electron transfer and coreactant activation for further ECL enhancement. After preparing MIL-101(Fe)@MoS <sub>2</sub> @TCPP nanoparticles (MMST), an ECL aptasensor is fabricated for 4-fluoromethamphetamine (4-FMA) determination relying on target-triggered cyanine dye displacement. This sensor exhibits an ultralow limit of detection of (1.87 × 10 <sup>− 15</sup> g/L) (S/N = 3) and a broad linear range from (1.0 × 10 <sup>− 14</sup> – 1.0 × 10 <sup>− 6</sup> g/L) g/L. It also shows favorable analytical results for real e-cigarette samples, with recoveries of 95.0–104.0% and relative standard deviations (RSD) less than 5.0%. This work offers a green route for high-performance PAH-based ECL luminophores and a reliable tool for rapid field screening of emerging psychoactive contaminants in complicated food-related matrices. </p>