Abstract
<title>Abstract</title> <p> Background Despite clinical guidelines, significant gaps persist in the standardized implementation of assessment and prophylactic measures. To address this complex medical challenge, we evaluated the impact of a standardised prevention and treatment system for VTE that integrates management frameworks, standardised processes, information technology (IT) support and staff training. Methods We analyzed monitoring data on the rate of standardized prevention of VTE and clinical outcome indicators for hospitalized patients between January 2021 and December 2023. Using the hospital’s full implementation of the VTE prevention and control information system and standardised prevention and treatment framework in April 2022 as the intervention point, divided into pre-intervention (January 2021 to March 2022) and post-intervention (April 2022 to December 2023). An interrupted time series (ITS) analysis with segmented regression models was employed to evaluate the intervention’s impact on standardized VTE prevention rates. Results The VTE risk assessment rate increased from 44.83% to 85.26%, and VTE prophylaxis implementation rate increased from 48.25% to 85.01% after intervention. ITS analysis indicated that the intervention produced a significant immediate effect, with the VTE risk assessment rate rising instantly by 23.228% (β = 23.228, <italic>t</italic> = 10.036, <italic>P</italic> < 0.001), and the VTE prophylaxis implementation rate increased immediately by 20.998% (β = 20.998, <italic>t</italic> = 8.353, <italic>P</italic> < 0.001); both metrics maintained a steady upward trend following the intervention. In terms of clinical outcomes, the incidence of DVT decreased from 1.98% to 0.72%, and the incidence of PTE decreased from 0.63% to 0.14%; both reductions were statistically significant ( <italic>P</italic> < 0.001). Conclusion Constructing and implementing a standardized VTE prevention and treatment system significantly improved the rate of standardized prevention of VTE, reduced the incidence of in-hospital VTE aderse events, and enhanced the quality of medical care. </p>