Abstract
<title>Abstract</title> <p>Crimean-Congo hemorrhagic fever (CCHF) is an emerging zoonotic disease caused by Crimean-Congo hemorrhagic fever virus (CCHFV), which is widely distributed across Asia, Africa, and Europe. The virus has been isolated from several species of ixodid (hard) ticks, and, as with other arboviral infections, most human infections arise from the bite of infected ticks. In addition, exposure to infected blood, tissues, or other body fluids significantly increases the risk of transmission. Despite a case-fatality rate of up to 30%, there are currently no licensed antiviral treatments or vaccines for CCHFV. In this study, we designed a domain-based vaccine targeting the M segment of CCHFV using an immunoinformatics-driven pipeline. Immune simulations demonstrated a strong and sustained immune response, suggesting the potential effectiveness of the proposed construct against CCHFV infection. However, further validation through in vitro and in vivo studies is essential to confirm its immunogenicity, safety, and overall efficacy.</p>