Abstract
<title>Abstract</title> <p> Aim This study aimed to identify latent psychological–spiritual resource profiles based on autonomous motivation, affective commitment, self-efficacy, and workplace spirituality, and to examine differences in nurse well-being across these profiles. Background Nurse well-being is shaped by multiple psychological and workplace resources. However, most previous studies have examined these resources separately, limiting understanding of how they combine within nurses. Methods A cross-sectional person-centered study was conducted with 203 nursing personnel at a tertiary care hospital in Pakistan. Latent profile analysis was performed using standardized scores for autonomous motivation, affective commitment, self-efficacy, and workplace spirituality. Nurse well-being was examined as a distal outcome using a three-step auxiliary approach. Exploratory chi-square analyses examined demographic differences across profiles. Results Four profiles were identified: Very Low Psychological–Spiritual Resource Profile, Low Psychological–Spiritual Resource Profile, Moderate Psychological–Spiritual Resource Profile, and High Psychological–Spiritual Resource Profile. The four-profile solution showed good classification quality, with entropy = .882 and strong classification probabilities. Nurse well-being differed significantly across profiles, Wald <italic>χ</italic> ²(3) = 347.00, p < .001. The High Psychological–Spiritual Resource Profile reported the highest well-being, whereas the Very Low Psychological–Spiritual Resource Profile reported the lowest well-being. Profile membership also differed across demographic characteristics, especially nursing experience, working position, age, and income level. Conclusion Nurse well-being varied according to combined psychological–spiritual resource patterns. The findings suggest that well-being interventions should move beyond general approaches and consider nurses’ motivational, commitment, efficacy, and workplace-spirituality profiles. </p>