Abstract
<title>Abstract</title> <p>Background Chronic kidney disease (CKD) is a growing public health problem in sub-Saharan Africa. Its progression to end-stage renal disease (ESRD) is life-threatening and places a considerable economic burden on patients and health systems. Identifying progression factors is essential to improve patient outcomes. Objectives To identify factors associated with CKD progression in hospitalized patients at CHUD-BA in Parakou in 2026. Methods Cross-sectional descriptive and analytical study with prospective data collection, conducted from March 15 to Jun 15, 2026, in the nephrology department. Progression was defined as a GFR decline ≥ 25% or advancement to a higher CKD stage (KDIGO 2012). Results 145 patients were included. Mean age was 52.3 ± 14.8 years with male predominance (58.5%). CKD progression was observed in 47.2% of patients. Factors independently associated with progression were: uncontrolled hypertension (OR = 4.12; 95%CI [2.08–8.16]; p < 0.001), type 2 diabetes (OR = 3.75; p < 0.001), proteinuria ≥ 1g/24h (OR = 5.60; p < 0.001), severe anemia (OR = 2.98; p = 0.004), and advanced CKD stage (OR = 6.44; p < 0.001). Conclusion CKD progression is frequent and multifactorial at CHUD-BA. Blood pressure control, proteinuria reduction, and anemia correction are the main therapeutic priorities to slow progression.</p>