Abstract
<jats:p>The resurgence in measles cases in the United States over the past couple of years has sparked concern among the populace in the sphere of increased hospitalizations and mortality rates despite the availability of a well tolerated and effective vaccine. Measles is a highly contagious viral disease which is spread through the air via aerosols and respiratory droplets and primarily affects younger individuals. A study was done to assess the effect of homeschooling and vaccination rates on Measles cases employing statistical tests multiple regression and Pearson correlation coefficient. Independent variables comprised MMR average vaccination rates from 2015 to 2025, and homeschooling data from 2024. Regression analysis revealed homeschooling had a significant effect on the number of measles cases (P=.004) with a positive correlation (r=0.4, P=0.01). The vaccination rate variable was not found to be statistically significant, however the correlation coefficient was positive (r=0.06, P&gt;0.05). These findings add to the current body of knowledge as researchers continue to explore causes for the recent spike in measles cases in the United States.</jats:p>