Abstract
<jats:p>IMGT®, the international information system® (https://www.imgt.org) (IMGT) was created in 1989 by Marie-Paule Lefranc (Université de Montpellier and CNRS) at Montpellier, France, to deal with and to manage the huge diversity of the immuno-globulins (IG) or antibodies and T cell receptors (TR), which are the antigen receptors (AR) of the adaptive immune response (AIR) of the jawed vertebrates. The founding of IMGT® marked the advent of immunoinformatics, a new science which emerged at the interface between immunogenetics and bioinformatics. The biocuration of the IMGT data (IG and TR sequences, genes and structures) and the implementation of the IMGT system (7 databases, 17 tools, 25,000 Web resources pages) are based on the IMGT Sci-entific chart rules (keywords, labels, nomenclature, numbering…) generated from the IMGT-ONTOLOGY axioms and concepts. The IMGT nomenclature (IMGT-NC) and the IMGT unique numbering, the two pillars of immunoinformatics, have been used to de-fine 335 engineered variants for effector properties and formats of therapeutic antibodies (including chimerisotypes) and TR, fusion proteins for immune applications (FPIA) and composite proteins for clinical applications (CPCA). IMGT engineered var-iants names from the World Health Organization (WHO) International Nonproprietary Name (INN) programme descriptions contribute to the common language for immunoinformatics and artificial intelligence (AI).</jats:p>