Abstract
<jats:p>Androgenetic alopecia is a progressive hair loss disorder characterized by reduced hair density and hair follicle miniaturization. Autologous blood concentrates, including platelet-rich plasma, platelet-rich fibrin, and concentrated growth factors, are increasingly utilized for wound healing and hair restoration. However, despite extensive clinical evidence, these therapies still lack a unified conceptual framework, and their underlying molecular mechanisms remain to be fully elucidated. This review summarizes the gradual optimization of platelet concentrates, while proposing extracellular vesicles as a potential key mediator in next-generation platelet concentrates. Moreover, we define the four core principles of “Instant Autologous Regenerative Medicine” and discuss the current limits and research priorities. This unifying framework will facilitate the development, standardization, and broader clinical application of point-of-care regenerative therapies.</jats:p>