Abstract
<jats:p>The Mass Action Law (MAL) Median Effect equation, fa/fu = (D/Dm)^m, leads to the Unified General Dynamics Theory and algorithm, which provides interdisciplinary and cross-disciplinary common linkage parameters for computerized, digital, efficient, cost-effective, Econo-green scientific R&amp;D and data science informatics. The MAL- general theory for drug and entity dynamics actions with common parameters (Dm and m); and dose-effect interaction in combinations with a unified combination index (CI), which allows digital simulation of synergism (CI &lt; 1), additive effect (CI =1), and antagonism (CI &gt; 1). The MAL-based input-output sequence, pattern transition, and combinatorics of enzyme reactions led to the discovery of the Second Degree (Squared) Pascal triangle. Surprisingly, life sciences dynamics can be linked to Riemann’s zeta hypothesis, ζ(s) at s = 2, for the critical line of prime distribution and the critical strip (0 – 1), and Euler’s Prime Product Function and its properties. The universe has two domains: Life and Non-Life, which manifest the dimensionless relativity ratio with basic codes. For life is a/b = a/(1-a) = (1-b)/b (Floating Ratio), and for Non-Life is a/b = (a + b)/a = 1 + b/a, or (Golden Ratio). Life and Non-Life can be linked by the two fractional finite and continuous distribution functions of “1”. Life is finite, discrete, and binary, cyclable with the Median-based equilibrium, symmetry, harmony, homeostasis, and optimal conditions; Non-Life is open, fractal, and extendable to infinity, as in mathematics, physics, and AI. Despite numerous mathematical equations having been derived and established since antiquity, the relevance of fundamental principles in biomedical science constitutes only a small fraction of them. Human existence constitutes a tiny fraction of the universe. However, humans evolve and decide the units and methods of measurement in all branches of science. This paper presents a unified MAL median-based top-down R&amp;D, distinct from traditional, statistics-based, bottom-up R&amp;D. The MAL input-output dynamics have yielded deterministic digital informatics through computer simulations and automation, with efficient, cost-effective features that are not accessible in traditional, specific-aimed, consensus-based regulated R&amp;D.</jats:p>