Abstract
<jats:p>Industry 5.0 offers new opportunities to rethink operational excellence by combining advanced technologies with sustainability, resilience, and human-centered value creation. This study examines how Industry 5.0 enabling technologies contribute to seven dimensions of operational excellence: efficiency and productivity, quality and reliability, organizational agility, continuous innovation, customer satisfaction, environmental sustainability, and organizational resilience. Based on survey data collected from 120 industrial companies that have begun integrating Industry 5.0 technologies, multiple regression analyses were conducted to assess the differentiated influence of these technologies on operational excellence outcomes. The results show that Industry 5.0 technologies do not contribute uniformly across all dimensions. Big Data emerges as a transversal lever, while Artificial Intelligence, Edge Computing, Digital Twins, Energy Efficiency Technologies, IoT, and Additive Manufacturing show more specific effects depending on the performance dimension considered. Environmental sustainability presents the strongest explanatory power, mainly supported by Energy Efficiency Technologies, Big Data, and Digital Twins. The findings suggest that Industry 5.0 adoption should follow a selective and contextual strategy aligned with firms’ operational, sustainability, and resilience objectives.</jats:p>