Figure 7 from Targeting the NAD<sup>+</sup> Salvage Pathway Blocks Metabolic Recovery and Enhances β-Lapachone Toxicity in NQO1-Expressing Glioblastoma Cells

<jats:p>&lt;p&gt;NQO1 and NAMPT expression is elevated in GBM. Gene expression data from TCGA-GBM and GTEx were accessed through UCSC Xena Browser. Normal brain tissue from noncancer patients (GTEx, &lt;i&gt;n&lt;/i&gt; = 1,142) were compared with primary IDH wild-type GBM tumors (&lt;i&gt;n&lt;/i&gt; = 140) and recurrent GBM tumors (&lt;i&gt;n&lt;/i&gt; = 13). &lt;b&gt;A,&lt;/b&gt; NQO1 expression in brain tissue. &lt;b&gt;B,&lt;/b&gt; NAMPT expression in brain tissue. Statistical significance was determined using ANOVA with the Dunnett multiple comparison test. **, &lt;i&gt;P&lt;/i&gt; &lt; 0.01; ****, &lt;i&gt;P&lt;/i&gt; &lt; 0.0001.&lt;/p&gt;</jats:p>