Figure 2 from DNA Methyltransferase Inhibition Prevents Platinum-Induced Ovarian Cancer Stem Cell Enrichment

<jats:p>&lt;p&gt;Transcriptomic analysis of OVCAR3 cells treated with platinum alone or in combination with DNMTi treatment. OVCAR3 cells were either untreated or treated with 15 μmol/L platinum for 16 hours, with or without 100 nmol/L DAC for 72 hours. Samples were then collected and subjected to RNA-seq (&lt;i&gt;N&lt;/i&gt; = 3). &lt;b&gt;A,&lt;/b&gt; Principal component analysis (PCA) plot of RNA-seq samples. Clustering of samples by (&lt;b&gt;B&lt;/b&gt;) similarity in expression profiles or (&lt;b&gt;C&lt;/b&gt;) expression of the 1,000 most variable genes. Heatmaps display the normalized enrichment scores of (&lt;b&gt;D&lt;/b&gt;) hallmark and (&lt;b&gt;E&lt;/b&gt;) STAT3 and NF-κB target gene sets for each treatment group relative to the untreated.&lt;/p&gt;</jats:p>