Figure S1 from Microsatellite Instable Cancer Cells Acquire On-target Resistance Mutations to WRN Helicase Inhibitors

<jats:p>&lt;p&gt;Related to figure 1. (A) SPR sensorgrams of WT WRN treated with AC1 and AC2. (B) DNA unwinding activity of wildtype WRN in the presence of AC1 and AC2. (C) Molecular docking of AC1 bound to the WRN helicase region (D) Viability of WRN dependent and independent cell lines treated with AC1 (left) or AC2 (right) after 3 days inhibitor treatment measured with CTG n=2 (E) Fold change γH2A.X immunofluorescence staining normalized to DMSO control in WRN dependent and independent cells treated with AC1 (left) or AC2 (right) for 3 days. n=2 for all lines except SW620 n=1&lt;/p&gt;</jats:p>