Figure S3 from Microsatellite Instable Cancer Cells Acquire On-target Resistance Mutations to WRN Helicase Inhibitors

<jats:p>&lt;p&gt;Related to figure 3. (A) Mean tumor volume measurements (± SEM) in a HRO71-resistant SW48 xenograft model treated with vehicle or 120 mg/kg HRO761 (n = 10 mice per treatment group). (B) Mean body weight of mice corresponding to figure 3A (C) Mean body weight of mice corresponding to figure S3A (D) Heatmap of WES results for tumors treated with HRO761 in Fig 3A, B (E) Experiment level mutation results of HRO761 resistance experiments (F) Sanger sequencing results of HRO761 dose ramp-up resistance experiments (G) SPR sensorgram of WRN WT and G729D treated with HRO761 (H) As in G with C727R (I) As in G with F730L (J) As in G with D526_P530del&lt;/p&gt;</jats:p>