<jats:p><p>The top hits by tandem mass tag (TMT)-labeled proteomics from the lurbinectedin sensitive cohort were evaluated for pathway enrichment based on ISL1 “high” versus ISL1 “low” signature. Gene Ontology (GO) analysis displays the most common pathways associated with the 142 proteins selected based on the threshold of |log2 ratio| >0.9 and P < 0.05.</p></jats:p>