Supplementary Figure S6 from Use of ctDNA in Older Women with ER+ Breast Cancer to Facilitate Surgical De-escalation: A Prospective, Hybrid-Decentralized Trial with Correlative Studies

<jats:p>&lt;p&gt;Supplementary Figure 6: (a) Pathway enrichment from the cancer epithelial cells in the responding TME. (b) Pathway enrichment of cancer epithelial cells in the progressing TME. (c) Detection of cancer cells harboring an ESR1 mutation in one patient progressing on pET. Both patients progressing on pET were tested. The other patient did not have an ESR1 mutations. (d) Pathways enriched in macrophages in the responding TME. Pathways in red indicate those from KEGG; blue are from REACTOME; and purple are from HALLMARK.&lt;/p&gt;</jats:p>