Abstract
<jats:p><p>Comparative analysis of urinary versus plasma-based metabolomic signature. <b>A,</b> Pairwise correlations between metabolite concentrations in matched plasma and urine samples (<i>n</i> = 161); r denotes Pearson’s coefficient. Asterisks indicate <i>P</i> < 0.05. <b>B,</b> Schematic of model comparisons using urinary metabolites and a previously established plasma signature. <b>C,</b> Time-dependent ROC curves of the urinary model, plasma signature, and combined model. AUC values indicate discriminatory performance for 60-month OS. To account for censoring before 60 months, AUC estimates were calculated using inverse probability of censoring weighting. Analysis was restricted to the complete-case cohort. (<b>B,</b> Image created with BioRender.com. Schwarz, F. [2026] <a href="https://BioRender.com/dy8x8k4" target="_blank">https://BioRender.com/dy8x8k4</a>.)</p></jats:p>