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Abstract

<jats:p>&lt;p&gt;Comparative analysis of urinary versus plasma-based metabolomic signature. &lt;b&gt;A,&lt;/b&gt; Pairwise correlations between metabolite concentrations in matched plasma and urine samples (&lt;i&gt;n&lt;/i&gt; = 161); r denotes Pearson’s coefficient. Asterisks indicate &lt;i&gt;P&lt;/i&gt; &lt; 0.05. &lt;b&gt;B,&lt;/b&gt; Schematic of model comparisons using urinary metabolites and a previously established plasma signature. &lt;b&gt;C,&lt;/b&gt; Time-dependent ROC curves of the urinary model, plasma signature, and combined model. AUC values indicate discriminatory performance for 60-month OS. To account for censoring before 60 months, AUC estimates were calculated using inverse probability of censoring weighting. Analysis was restricted to the complete-case cohort. (&lt;b&gt;B,&lt;/b&gt; Image created with BioRender.com. Schwarz, F. [2026] &lt;a href="https://BioRender.com/dy8x8k4" target="_blank"&gt;https://BioRender.com/dy8x8k4&lt;/a&gt;.)&lt;/p&gt;</jats:p>

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Keywords

urinary signature plasma model analysis

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