Supplementary Figure S2 from Consistent Metabolomic and Genetic Evidence Supports Acisoga as a Key Contributor to Colorectal Neoplasia Progression

<jats:p>&lt;p&gt;Supplementary Figure S2. Stratified analysis of Acisoga levels across colorectal neoplasia stages. Log2-transformed Acisoga intensities across diagnostic groups (C, controls; LRL, low-risk lesions; IRL, intermediate-risk lesions; HRL, high-risk lesions; CRC, colorectal cancer), stratified by participant characteristics. a) Sex: males (purple triangles) and females (coral diamonds). b) Age: &lt;61 years (blue triangles) and ≥61 years (light green diamonds). c) Body mass index (BMI): &lt;27.7 kg/m² (orange triangles) and ≥27.7 kg/m² (dark pink triangles). d) Alcohol intake: &lt;5.5 alcohol g/day (maroon triangles) and ≥5.5 alcohol g/day (dark green diamonds). Black circles represent mean intensities for all individuals.&lt;/p&gt;</jats:p>